Emine Erdag
Near East University Faculty of Pharmacy, North Cyprus
Title: Studies on new 2(3H)-benzoxazolone derivatives: synthesis, characterization and cytotoxic effects
Biography
Biography: Emine Erdag
Abstract
2(3H)-Benzoxazolone derivatives have been reported to show diverse biological activities depending on the position and type of the substituent. Recent studies show that these types of molecules could also show promising anticancer activities. A series of new Mannich bases of 2(3H)-benzoxazolone derivatives have been prepared. These molecules have piperazine group at the third position of the core structure. The structural characterization of these compounds was performed by FT-IR, 1H NMR and ESI-MS analysis. These 2(3H)-benzoxazolone derivatives were analyzed for their cytotoxicity toward MCF-7 cancer cell line. Different concentrations of these molecules were incubated for 24 h and 48 h. MTT assays were employed to measure cytotoxicity and cell growth. Our results showed that, among all concentrations of 2(3H)-Benzoxazolone derivatives studied (5, 10, 20, 50 and 100 μg/ml), dimethylphenylpiperazine substituted derivative, at 50 μM concentration was more effective at inhibiting MCF-7 cell growth compared with other dilutions for 24 h and 48 h incubation period.