12^th International Conference on Medicinal Chemistry and Drug Discovery October 14-15, 2020 Munich, Germany

Track: 1 Medicinal Chemistry and Drug Discovery:

Medicinal Chemistry is commonly an interdisciplinary science, and pros have a solid foundation in natural science, which should as time goes on to be united with a wide comprehension of characteristic musings related to cell steady targets. Research analyst in medicinal chemistry work is fundamentally present-day researchers, filling in as a segment of an associative social event that utilizes their science limits, particularly, their built limits, to utilize substance measures to design effective therapeutic agents. Medicinal Chemistry in its most essential work on minimal regular particles —incorporates built synthetic organic and parts of trademark things and computational science in the close mix with chemical biology, and fundamental science, enzymology together with going for the disclosure and headway of new healing authorities. Pharmacognosy and pharmacology, toxicology and veterinary and human prescription.

• Synthesis and Catalysis
• Organic Synthesis
• Applied Chemistry
• Manufacturing and Marketing OTC Drugs

Track: 2 Pharmaceutical Chemistry:

The pharmaceutical sciences are a gathering of interdisciplinary regions of concentrate worried about the diagram, action, conveyance, and emanation of medications.  The drug store is the science and strategy of getting ready and administering drugs. It is prosperity calling those affiliations' prosperity sciences with compound sciences and would like to guarantee the secured and doable utilization of pharmaceutical drugs.

Pharmaceutical science is the study of drug compounds, and it includes the drug development process. This includes drug discovery, delivery, absorption, metabolism, distribution, and excretion. There are components of biomedical investigation, pharmacology, pharmacokinetics, and pharmacodynamics. Pharmaceutical science work is generally done in lab conditions it, for the most part, includes fixes and solutions for illness, expository strategies, pharmacology, digestion, quality control, quality affirmation, and drug chemistry. The level of medicine store sharpen consolidates more standard parts, for example, compounding and assigning courses of action, and it in addition joins increasingly present-day associations identified with social insurance, including clinical associations, reviewing solutions for security and sufficiency, and giving drug information.

• Pharmaceutics, Drug Delivery, and more
• Bio pharmaceutics and Pharmacokinetics
• Regenerative Medicine and Technology
• Drug Delivery and Material Sciences

Track: 3 Analytical Chemistry:

Analytical Chemistry involves the separation, identification, and the quantification of matter. It involves the use of classical methods along with modern methods involving the use of scientific instruments.

Analytical chemistry involves the following methods:

• The process of separation isolates the required chemical species which is to be analyzed from a mixture.
• The identification of the analyte substance is achieved via the method of qualitative analysis.
• The concentration of the analyte in a given mixture can be determined with the method of quantitative analysis.

Traditional subjective strategies utilize partitions procedures, for example, precipitation, extraction, and refining. Recognizable proof might be founded on contrasts in shading, scent, liquefying point, breaking point, radioactivity or reactivity. Instrumental strategies might be utilized to isolate tests utilizing chromatography, electrophoresis or field stream fractionation. At that point qualitative and quantitative investigation can be performed, frequently with a similar instrument and may utilize light cooperation, warm communication, electric fields or attractive fields.

• Analytical Techniques for Clinical Chemistry
• Chemical Analysis
• Mass spectrometry
• Electrochemical analysis
• Spectroscopy
• Separation Techniques

Track: 4 Biological Drug Targets:

The term biological target is additionally utilized as a part of pharmaceutical research to depict the common protein in the body whose action is altered by a drug bringing about an impact at a particular site, which might be a satisfactory helpful impact or an unnecessary adverse effect. Directed drug conveyance frameworks have been produced to improve regenerative strategies. Various types of drug targets are:

• Nucleic Acids
• G-protein coupled receptors
• Liposomes
• Nanoparticles

Track: 5 Pharmacokinetics and Pharmacodynamics:

Pharmacokinetics is a branch of pharmacology dedicated to determining the fate of substances     administered to a living organism.

Pharmacodynamics is the study of the biochemical, physiological, and molecular effects of drugs on the body and involves receptor binding post receptor effects, and chemical interactions.

The term pharmacodynamics refers to the relationship between drug concentrations at the site of action (receptor) and pharmacologic response. Pharmacodynamics includes the biochemical and physiologic effects that result from the interaction of the drug with the receptor. More number of drugs share the same metabolic pathways or target the same receptors. This leads to the occurrence of pharmacokinetic and pharmacodynamic differences, respectively. Drug–drug interactions occur mainly during drug absorption, distribution (plasma drug binding protein), biotransformation and excretion.

• Drug transportation reactions
• Bioavailability
• Antimicrobial pharmacodynamics
• Human physiology and drug metabolism
• Pharmacokinetic/Pharmacodynamic modelling
• Drug Interaction and Pharmacological compatibilities

Track: 6 Organic Chemistry:

Organic Chemistry is the investigation of the structure, properties, arrangement, responses, and readiness of carbon-containing mixes, which incorporate hydrocarbons as well as mixes with any number of different components, including hydrogen (most mixes contain somewhere around one carbon-hydrogen security), nitrogen, oxygen, incandescent light, phosphorus, silicon, and sulfur. Organic Chemistry is an exceedingly inventive science in which scientists make new atoms and investigate the properties of existing mixes. Natural mixes are surrounding us. They are fundamental to the financial development of the United States in the elastic, plastics, fuel, pharmaceutical, beautifying agents, cleanser, coatings, dyestuff, and agrichemical ventures, to give some examples.  Numerous cutting edges, innovative materials are at any rate incompletely made out of natural mixes.

• Natural products synthesis
• Synthetic methodology
• Catalysis
• New synthetic technologies
• Medicinal Chemistry and Chemical Biology
• Synthesis of Nano- and functionalized Materials

Track: 7 Drug Design and Drug Development:

Drug design, as often as possible insinuated as an adjusted prescription blueprint or basically rational arrangement, is the inventive methodology of finding new pharmaceuticals in perspective of the data of a natural target. The prescription is most typically a characteristic little particle that starts or curbs the limit of a biomolecule, for instance, a protein, which accordingly achieves a remedial favorable position to the patient.

Drug development is the path toward passing on another pharmaceutical drug to the market once a lead compound has been perceived through the method of drug discovery. It joins pre-clinical research on microorganisms and animals, requesting of for authoritative status, for instance, by methods for the United States Food and Drug Administration for an investigational new pharmaceutical to begin clinical fundamentals on individuals, and may consolidate the movement of getting regulatory support with another prescription application to feature the solution.

• Molecular Modeling
• Kinase Inhibitor Chemistry
• Blood-Brain Penetrant Inhibitors
• GPCR-Targeted Drug Design
• Protein-Protein Interactions
• Inflammation Inhibitors
• Small Molecules for Cancer Immunotherapy
• Biophysical Approaches for Drug Discovery
• Macrocyclic & Constrained Peptides
• Fragment-Based Drug Discovery
• Medicinal and Bioorganic Chemistry
• Biomarkers & Clinical Research

Track: 8 Drug Delivery Techniques:

A drug’s efficacy can be impacted significantly by the way in which it is delivered. By developing a variety of drug delivery systems (DDSs) it is now possible to better control the pharmacokinetics, pharmacodynamics, immunogenicity, toxicity and efficacy of drugs.

By finding the best-suited delivery system for a specific drug molecule it is possible to “optimize” the performance of that drug inside the body.  Here the different administration methods, discover what is meant by a "drug delivery system", and highlight key drug delivery “vehicles”. Drugs can be introduced into the body via several different routes. These routes are generally classified by their “starting point”, the location at which the drug is administered. Each route has its own advantages and disadvantages.

• Buccal drug delivery
• Nasal drug delivery 
• Ocular drug delivery 
• Oral drug delivery
• Pulmonary drug delivery
• Sublingual drug delivery
• Transdermal drug delivery
• Vaginal/anal drug delivery
• Targeted drug delivery

Track:9 Nano Medicine and Nanotechnology:

Nanomedicine is the interdisciplinary field of science, restorative use of a Nanotechnology, which incorporates diagnosing, treating and forestalling malady and horrible damage, mitigating torment and saving and enhancing human wellbeing utilizing atomic instruments and sub-atomic learning of the human body. It manages the structure running from 1nm to 100nm. It has an extensive variety of use in medicinal fields like medication conveyance, Cancer treatment, Imaging, Sensing, Blood refinement, Tissue designing, and Medical gadgets.

The use of nanotechnology in medicine provide some exciting possibilities. Some techniques are only visualized, while others are at various stages of testing, or being used today. Nanotechnology involves in medicinal applications of nano particles currently under development, as well as longer range research that involves the use of manufactured nano-robots to make repairs at the cellular level. The use of nanotechnology in the field of medicine could transform the way we detect and treat damage to the human body and disease in the future, and many techniques only visualized a few years ago are making remarkable progress towards becoming realities.

• Advanced Nanomaterial
• Nanotechnology applications
• Nanomaterials safety and regulations
• Nanomaterials Characterization and Synthesis
• Nanodevices and Systems
• Biomedical Nanomaterial

Track: 10 Computer Aided Drug Design:

Utilization of computational procedures in drug revelation and advancement process is quickly picking up in fame, usage and appreciation. Diverse terms are being connected to this region, including Computer-Aided Drug Design (CADD), computational medication plan, Computer-Aided Molecular Design (CAMD), Computer-Aided Molecular Modeling (CAMM), discerning medication outline, in the silico sedate plan, computer-aided rational drug design. Term Computer-Aided Drug Discovery and Development (CADDD) will be utilized in this diagram of the territory to cover the whole procedure. Both computational and experimental techniques in chemistry have essential parts in drug discovery and drug development and speak to reciprocal methodologies.

• Structure-Based Computer-Aided Drug Design
• Ligand-Based Computer-Aided Drug Design
• Computational Medicine Plan
• Computer Aided Molecular Design
• Computer-Aided Molecular Modeling
• Computer-Aided Drug Discovery and Development

Track: 11 Novel Target Drugs to The Treatment of Cancer:

Directed disease treatments are drugs or other therapeutic substances which hinders the development and spread of tumor by hindering with the particles called sub-atomic targets which are associated with the development, movement and spread of malignancy. In this manner, advancement of novel-tumor ligand or pharmaceutical Nano bearers is very alluring. Hostile to disease drugs are likewise called Anti neoplastic-operators or Chemotherapeutic-specialists. Directed conveyance of medications to tumors speaks to a noteworthy progress in Cancer analysis and treatment and utilizations data about a man's qualities and proteins to anticipate, analyze and treat infection.

• Gene expression modulators
• Signal transduction inhibitors
• Angiogenesis Inhibitors
• Monoclonal Antibodies
• Immunotherapies
• Limitations of targeted cancer therapies
• Side effects of targeted cancer therapies
• Clinical trials of cancer targeted therapies
• Hyphenated techniques

Track: 12 Medicinal Plants:

Medicinal plants, likewise, called restorative herbs, have been found and utilized in customary prescription practices since ancient occasions. Plants blend several synthetic mixes for capacities including safeguard against bugs, organisms, illnesses, and herbivorous warm-blooded animals. Various phytochemicals with potential or establish natural movement have been identified. However, since a solitary plant contains generally various phytochemicals, the impacts of utilizing an entire plant as drug are dubious. Further, the phytochemical content and pharmacological activities, assuming any, of numerous plants having restorative potential stay unassisted by thorough logical research to characterize viability and security. In the United States over the period 1999 to 2012, in spite of a few hundred applications for new medication status, just two herbal medication competitors had adequate proof of therapeutic incentive to be endorsed by the Food and Drug Administration.

• Poisonous Medicinal Plants
• Medicinal Plants as Medicine
• Medicinal Plants as Anti-Cancer Drugs
• Traditional medicine
• Herbal Medicine and technology
• Herbal Sciences
• Aromatic Plant Sciences
• Phytochemical Evaluations
• Naturopathic Medicine
• Natural Products Research
• Ayurvedic Medicinal Plants

Track: 13 Gynecological Drug Therapy:

Gynecological drug therapy is involved in the treatment of the following diseases like vaginal infections, genital herpes, genital warts, pelvic inflammatory disease, urinary infections, pruritus vulvae, menstrual problem and infertility. Pre-and post-usable medicinal administration will frequently utilize numerous standard medication treatments, for example, diuretics, antihypertensive, anti-infection agents and antiemetic’s. Gynecologists use specialized hormone-modulating therapies to treat disorders of the female genital tract.

• Pharma in treatment of gynecologic oncology
• Complementary and alternative medicines in gynecology
• Medical problems in pregnancy
• Hormonal replacement therapy
• Stem cells in gynecology

Track: 14 Biological Drugs in Autoimmune Disease:

Huge progression has been made in the treatment of immune system sicknesses by presenting novel, for the most part biologic, sedates instead of substance particles. Biologic agents are biologically emerged and used therapeutically. Most of these agents are based on receptor proteins or antibodies. Biologic therapies help in the treatment of lupus erythematous, rheumatoid arthritis, multiple sclerosis, Grave's disease, and inflammatory bowel disease.

• Autoimmune and inflammatory disorders
• Biologic drugs in Rheumatoid arthritis
• Autoimmune Diseases induced by TNF-Targeted therapies
• Drawbacks of biologic therapies
• Adverse effects and safety

Track: 15 Clinical and Hospital Pharmacy:

Clinical drug store is a field which manages the medicine and patient consideration. Advances wellbeing, health and sickness treatment. It comprises of the considerable number of administrations like drug specialists rehearsing in nursing homes, network drug stores, emergency clinics, locally established consideration administrations, facilities and some other setting wherever prescriptions are endorsed and utilized.

Emergency clinic Pharmacies are the segment of the pharmaceutical consideration the board in emergency clinics, which depicts the systems in which meds are chosen, gotten, conveyed, endorsed, directed and checked on to advance the commitment of those drugs.

Clinic drug stores for the most part store an expansive scope of meds, including progressively specific and investigational meds.

• Therapeutic drug monitoring
• Rational drug use
• Pharmaceutical care
• Developments in Clinical Pharmacy to Meet Emerging Challenges
• Industrial pharmaceutics
• Clinical Trials

Applications of Medicinal Chemistry:

Therapeutic science is an Interdisciplinary science which is having solid background in natural science. It Constitutes the distinguishing proof of novel natural mixes. Restorative Chemistry characterized to the examination and the impacts of medications in huge quantities of individuals populace level. Restorative Chemistry applies the techniques for the study of disease transmission to the substance zone of clinical pharmacology. The study of disease transmission strategies for request, Clinical pharmacology on focal point of request, Applies the techniques for the study of disease transmission to the substance territory of clinical pharmacology. Therapeutic Chemistry autonomously and as a calling have significant positions to play in Studying Cause and Effect, Risk Association Studies, Studies of Drug Utilization, Evaluating and Improving Physician Prescription, Assessment of Patient Compliance, Studies of Medication Errors, and so forth. Therapeutic Chemistry is a powerful apparatus to catch helpful information for clinicians, specialists and approach producers.

Medicinal and pharmaceutical chemistry is a scientific discipline at the interaction of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Areas of interests include target discovery and validation, drug design, virtual screening, molecular modeling, drug-receptor interactions; organic synthesis of bioactive compounds, bioassay method development, molecular insights to drug action and metabolism, natural products chemistry, prodrug synthesis and drug targeting. The process of drug discovery involves the synthesis, identification of candidates, characterization, screening, and assays for therapeutic efficacy. The science of medicinal chemistry involves the design and synthesis of novel drugs based on an understanding of how drugs work in the body at the molecular level. Medicinal Chemistry is a multifaceted discipline that encompasses synthetic organic chemistry, natural products chemistry, enzymology, chemical biology, structural biology and computational methods, all of which is aimed at the discovery and development of new therapeutic agents. The techniques are used in the fields of computational chemistry, computational biology, drug design and materials science for studying molecular systems ranging from small chemical systems to large biological molecules and material assemblies. Nowadays, drug design and development are followed by QSAR analysis, optimizing pharmacokinetic and pharmacodynamic properties. Finally, the varieties of chemistry have contributed to life processes and to the efforts to advance the quality of life as well as to the development of society from synthetic, medicinal, pharmaceutical point of view.

Medicinal Chemistry for Drug Discovery Market: Overview

In the course of the most recent decade, industry's efficiency has been declining with rising R&D expenses and time taken to arrive at market. Restorative science is characterized as an engaged science that is created to cover a wide scope of fields related with distinguishing proof, combination and medication advancement for helpful applications. This science has developed from therapeutic scientists concentrating on medication target or pathway as a primary concern and class of elaborative science driven procedures to present day age of high-throughput screening (HTS) libraries that are made by combinatorial science dependent on couple of basic qualifications crosswise over enormous medication like frameworks.

This change was required as a result of high wearing down rate in pre-clinical and brooding medication improvement examines considering prior techniques. While the essential undertaking of therapeutic scientists has not changed altogether over some stretch of time, the computational devices and synthetic compounds and points of view at their freedom or expulsion have progressed broadly.

The different instruments of therapeutic science are in silico displaying, structure-based medication plan (SBDD), near sub-atomic field investigation (CoMFA) or 3D QSAR strategy. Specifically, the part-based medication configuration promisingly stands out on account of generous enhancements in research and efficiency. One of the essential difficulties of medication revelation is to plan a hearty medication that is both protected and viable in a wide scope of populace. The different medication planning types are structure-based medication, common items-based medication configuration, part-based medication plan, assorted variety arranged union and chemo genomics.

Medicinal Chemistry for Drug Discovery Market: Trends

Because of present day innovation an elective way to deal with the huge combichem libraries (10,000 or more atoms) is accessible, these are littler centered exhibits known as chemo genetic clusters that helps for limiting of specific pharmacophore model for explicit family to target yet considering ADME and medication like properties. The compound clusters must be artificially possible and to limit the steady loss rate in preclinical testing, should likewise comprise of explicit properties with respect to adsorption, dispersion, digestion, end and lethality (ADMET).

Science volumes continue ascending in the U.S. additionally, compound market foreseen that would get this year—in like manner, substance industry capital spending in the U.S. flooded 12.1% out of 2014 and expanded 21.0% out of 2015, accomplishing $43.58 billion and speaking to more than one-bit of total advancement spending by the gathering division. The association addressing US-based engineered producers said that US invention age (notwithstanding pharmaceuticals) is depended upon to comprehend the general improvement of 1.6% out of 2016, trailed by 4.1% advancement one year from now, and 5.0% out of 2018. Ordinary yearly gets of over 8% consistently in U.S. Substance industry capital spending is typical through 2018 with only a minor log jam in coming about advancement foreseen. By 2021, ACC foresees that capital spending will reach $70 billion, adding to four progressive long periods of occupation advancement in the business. American science salaries will outperform $1.0 trillion by 2020.

This International Conference on Medicinal Chemistry and Rational Drugs bases on the hugeness to fathom drugs supportive, Cell Line Development and choices in the Research and Teachings, subsequently in what capacity may we help the use of cell line models and besides extraordinary other checking perspectives in inventive work. It is with better understandings, not only one can know the customary systems for pharmacology yet, what's more, the Clinical Trails and Experimental philosophies in investigate without the utilization of animals and after that again with the use of Cell Line models. More research in pharmacology figures out how to perceive and investigates in Drug Development, Cell Line Preservation and usage as time goes on, in vitro, in silica models, non-prominent frameworks, littler scale dosing. Even more abnormally the Traditional techniques for Pharmacology and the biotechnology investigate now achieving the Advancement and New Trends.

We gratefully to thank all our wonderful Speakers, Conference Attendees, Students, Media Partners, and Associations for making Euro Medicinal Chemistry 2019 Conference the best ever!

The 11^th International Conference on Medicinal Chemistry and Pharmaceutical Technology

was held during  April 01-02, 2019 at Prague, Czech Republic

based on the theme “Deliberate the challenges in the New era of Optimizing Medicinal Chemistry & Drug Design Research Reforms ". Benevolent response and active participation were received from the Committee Members along with Professors, Researchers, Students and leaders from various fields of Medicinal Chemistry, who made this event a grand success.

Euro Medicinal Chemistry expresses its gratitude to the conference Moderator, namely LIM Swee Hua Erin for taking up the responsibility to coordinate during the sessions. We are indebted to your support.

The conference was initiated with the Honorable presence of the Keynote forum. The list includes:

• Dr. Roberto Di Santo University of Rome “La Sapienza”, Italy
• Dr. Roberto Hasane, F. Hoffmann-La Roche Ltd., Switzerland

The meeting reflected various sessions, in which discussions were held on the following major scientific tracks:

• Design of inhibitors targeting Coronavirus main proteases.
• Utilizing essential oils for mitigation of AMR.
• E-BABE-The study of chemotherapeutic activity of the ginsenoside Rh2 from ginseng root and "Doxorubicin" combination treatment.
• Using structural biology of methanogen enzymes to guide development of inhibitors for mitigating methane emissions and to enhance our understanding of methane formation.
• Effects of Spirulina platensis on the immune status, anti-inflammatory and oxidative markers in HIV patients on antiretroviral therapy in Cameroon.
• Discovery of natural autoinducers mimics by Pseudomonas aeruginosa LasR quorum- sensing signaling receptor via structure based virtual screening.

Euro Medicinal Chemistry 2019 Conference offers its heartfelt appreciation to Committee Members, Honorable Guests, Chair & Co-chair, various outside experts, company representatives; eminent personalities who interlaced with Conference and supported the conference in every aspect, without your support the conference would not be possible.

Your rejoinder is our inspiration; keeping this motto in mind and being witnessed the triumph of Euro Medicinal Chemistry 2019.

Euro Medicinal Chemistry 2019 Conference would like to announce the commencement of the “Euro Medicinal Chemistry 2020.” Webinar to be held during October 14-15, 2020. we welcome all the eminent researchers, students and delegate participants to take part in this upcoming conference to witness invaluable scientific discussions and contribute to the future innovations in the field of Medicinal Chemistry.

For More details:  https://medicinalchemistrymeetings.pharmaceuticalconferences.com/

Let us meet again @ Euro Medicinal Chemistry 2020